Atlas of Ophthalmology

Normal Pressure Glaucoma with Silent Cerebral Infarcts (Colour Fundus Photography, Perimetry, OCT, MRI)

Glaucomas, Ocular Hypertension -> Primary Chronic Open-Angle Glaucoma (POAG) -> Low-Tension Glaucoma
Patient: 62 years of age, male, BCVA 0.7 at OD, 0.5 at OS, IOP 16/16 mmHg, pachymetry 503/502 µm. Ocular Medical History: never IOP-values greater than 16 mmHg. General Medical History: arterial hypertension. Major complaints: deep focal scotoma. Purpose: to present a patient with normal pressure glaucoma with disc hemorrhages and silent cerebral infarcts. Methods: Colour Fundus Photography, w-w-perimetry (Octopus), OCT (Spectralis, HE, Heidelberg), MRI (TimTrio, 3-Tesla, Siemens). Findings: Colour Fundus Photography: Glaucomatous optic nerve atrophy and parapapillary disc hemorrhages. Ww-visual field: Focal scotoma, fitting to location of thinned retinal nerve fiber layer. OCT circular scan: superior and inferior thinning of retinal nerve fiber layer. MRI: White matter lesions (silent cerebral infarcts) in area of optic tract (arrow). Discussion: Leung et at. (1) investigated whether the presence of silent cerebral infarct is related to field progression in normal-tension glaucoma (NTG). He found that presence of silent cerebral infarcts are an independent risk factor for visual field progression in patients with NTG. Disc hemorrhage, silent cerebral infarcts, systemic arterial hypertension, and CCT were associated with field progression. Literature: (1) Leung DY, Tham CC, Li FC, Kwong YY, Chi SC, Lam DS. Silent cerebral infarct and visual field progression in newly diagnosed normal-tension glaucoma: a cohort study. Ophthalmology. 2009 Jul;116(7):1250-6

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