Female, 60 years of age, BCVA 0.6, IOP 16 mmHg, decrease of VA since 9 months, metamorphopsia, arterial hypertension. (1) Initial fundus photograph shows reddish-orange nodules. (2) Indocyanine green angiography shows a branching vascular network that terminates in polypoidal lesions. (3) A vertical optical coherence tomography section through the fovea reveals sharp protrusions of the retinal pigment epithelium due to polypoidal lesions. A branching vascular network is seen as flat protrusions. Polypoidal choroidal vasculopathy (PCV) is recognized as a distinct clinical entity, differing from exudative AMD. PCV is a branching vascular network that terminates in polypoidal lesions seen on indocyanine green angiography. PCV is more common in Asians than in Caucasians. The treatment effects of anti-VEGF agents on the vascular lesions of PCV are limited in short-term follow-up. In contrast, studies have shown encouraging results of PDT for the treatment of PCV (1,2). The diagnosis of PCV is based on indocyanine green angiography, which shows a branching vascular network terminating in polypoidal dilation. Literature: (1) Nakata I, Tsujikawa A, Yamashiro K, Otani A, Ooto S, Akagi-Kurashige Y, Ueda-Arakawa N, Iwama D, Yoshimura N. (2012) Two-year outcome of photodynamic therapy combined with intravitreal injection of bevacizumab and triamcinolone acetonide for polypoidal choroidal vasculopathy. Graefes Arch Clin Exp Ophthalmol. 2012 Aug 25. (2) Chan WM, Lam DS, Lai TY, Liu DT, Li KK, Yao Y, Wong TH (2004) Photodynamic therapy with verteporfin for symptomatic polypoidal choroidal vasculopathy: one-year results of a prospective case series. Ophthalmology 111:1576–1584