Patient: 50 years of age, female, BCVA 0.4 at OD, 0.5 at OS; IOP 15/15 mmHg General Medical History: biopsy confirmed diagnosis of tubulointerstitial nephritis, arterial hypertension; therapy with steroids from 02/2013 to 10/2013, in 11/2013 vision reduction, redness, and photophobia. Ocular Medical History: Approximately 8 months of tubulointerstitial nephritis symptoms red, photophobic eyes of 2 weeks duration, OD>OS. Uveitis responded well to topical steroid and cycloplegic treatment. Follow-up examinations showed a gradual decrease in the inflammation, with no ocular complications. Main Complaint: vision reduction, redness, and photophobia. Findings: Colour photography cornea (OD): mildly injected conjunctivae bilateral, small, round keratic precipitates in nongranulomatous anterior-segment inflammation. Colour photography cristalline lens (OD): lenticular pigmentation after posterior synechiae in nongranulomatous anterior-segment inflammation. Discussion: Uveitis in association with tubulointerstitial nephritis is a distinct clinical entity known as tubulointerstitial nephritis and uveitis (TINU) syndrome. It is considered to be a rare disease and thus unfortunately is still unfamiliar to most ophthalmologists. The onset of uveitis most commonly follows the onset of the interstitial nephritis, but may also occur before or concurrently. The uveitis is usually bilateral, nongranulomatous, limited to the anterior segment. TINU generally responds well to topical or oral anti-inflammatory treatment. Johnson et al. (1) suggested, that TINU syndrome as an under-recognized disorder may account for some cases of uveitis otherwise characterized as 'idiopathic." The uveitis may be the presenting sign in up to 36% of cases of TINU syndrome. Prompt detection through referral or testing will allow speedy diagnosis and appropriate treatment for both the uveitis and the tubulointerstitial nephritis. The cause of the disease is still unknown. A hypersensitivity reaction is suspected, especially an infection is thought to trigger the disease. Mackensen et al. (2) showed advances in diagnostics. Beta-2 microglobulin (Ub2MG) analysis in urine and human leukocyte antigen (HLA) typing is helpful to diagnose TINU cases. A high association of HLA-DRB1*01 has been shown with TINU. Literature: (1) Johnson BS, Austin JK, Pizio HF. Tubulointerstitial nephritis and uveitis syndrome. Optometry. 2003 Apr;74(4):240-4. (2) Mackensen F, Billing H. Tubulointerstitial nephritis and uveitis syndrome. Curr Opin Ophthalmol. 2009 Nov;20(6):525-31.