Atlas of Ophthalmology

Epibulbar and Choroidal Lymphoma (Colour Photography Anterior Segment, Colour Photography Posterior Segment, OCT, Ultrasound, Histology)

Coroides -> Tumores -> Maligne Tumoren
Patient: 67 years of age, male, BCVA 0.3, IOP 16 mmHg. Ocular Medical History: blurred vision at OS, salmon-colored subconjunctival lesion of the left eye consistent with an epibulbar lymphoma. After incisional biopsy and surgical tumor reduction a fractionnated stereotactical radiotherapy of left orbita inclusive left eye was performed with a total dose of 40 Gy (single dose of 2,0 Gy). General Medical History: no relevant events, systemic lymphoma was absent. Major complaint: blurred vision at OS. Purpose: to report the clinical, ultrasonographic, and histological features of choroidal lymphoma . Methods: Colour Photography Anterior Segment, Colour Photography Posterior Segment, OCT, Ultrasound, Histology. Findings: Colour Photography Anterior Segment: transscleral epibulbar (extraocular) extension, visible as a pink mass under the conjunctiva and tenon fascia. Colour Photography Posterior Segment: multifocal creamy-yellow infiltrates at the level of choroid. Optical coherence tomography: irregular choroidal contour over the area of choroidal infiltration, subretinal fluid involving more than 1 quadrant. B-scan ultrasonography: choroidal thickening with relative acoustic hollowness and focal areas of posterior epibulbar extension, maximum tumor thickness of 2.6 mm. Histology: Hematoxylin-eosin, subepithelial small, monomorphic lymphoid cells. Discussion: Proliferation of lymphoid cells in the uveal tract is rare. The presence of multifocal creamy-yellow patches at the level of choroid is probably the most helpful funduscopic feature for establishing the correct diagnosis of early choroidal lymphoma . Mashayekhi A et al. concluded that patients with choroidal lymphoma, and no known systemic lymphoma at presentation should undergo systemic evaluation to rule out the possibility of undiagnosed concurrent systemic lymphoma. They found that the most common form of initial treatment was external beam radiotherapy, followed by some form of systemic treatment. Literature: (1) Mashayekhi A, Shukla SY, Shields JA, Shields CL. Choroidal lymphoma: clinical features and association with systemic lymphoma. Ophthalmology. 2014 Jan;121(1):342-51.

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