Patient: 35 years of age, female, BCVA 0.3 at OD, 0.6 at OS. Ocular medical history: deterioration of vision over three weeks. General medical history: A biopsy showed a non-small-cell lung carcinoma. A bone gammagraphy revealed multiple skeletal metastases. MRI showed a pleural infiltration. The patient is currently receiving chemotherapy. Due to ocular findings begin of another chemotherapy and radiation. Main complaint: deterioration of vision. Purpose: to show clinical findings of bilateral choroidal metastases and the effect of chemotherapy and radiation on associated serous retinal detachment. Method: Patient undergone colour photography and spectralis-OCT before and after chemotherapy and radiation. Findings: 1) Colour photography OD 4.3.2013: revealing yellow choroidal metastases (*) with associated serous retinal detachment (arrows). 2) Colour photography OS 4.3.2013: revealing yellow choroidal metastases (*) with associated serous retinal detachment (arrows). 3) Colour photography OD & OS 4.3.2013: A funduscopic examination revealed yellow choroidal metastases (*) in the right and left eye with associated serous retinal detachment (arrows). 4) Mosaic from Colour photography and OCT of OD 4.3.2013: yellow choroidal metastases (*) with associated serous retinal detachment (arrows). 5) Mosaic from Colour photography and OCT of OS 4.3.2013: yellow choroidal metastases (*) with associated serous retinal detachment (arrows). 6) OCT of OD 4.3.2013: serous retinal detachment including macular area. 7) OCT of OS 4.3.2013: serous retinal detachment including macular area. 8) MRI: lung carcinoma with pleural infiltration. 9) Mosaic from colour photography OD from 4.3.2013 and 2.4.2013: effect of chemotherapy and radiation, comparing images from 4.3. 2013 and 2.4.2013 there is a reduction of serous retinal detachment associated with choroidal metastases (*). 10) Mosaic from colour photography OS from 4.3.2013 and 2.4.2013: effect of chemotherapy and radiation, comparing images from 4.3. 2013 and 2.4.2013 there is a reduction of serous retinal detachment associated with choroidal metastases (*). 11) Mosaic from OCT OD & OS from 4.3.2013 and 2.4.2013: effect of chemotherapy and radiation, comparing images from 4.3. 2013 and 2.4.2013 there is a reduction of serous retinal detachment associated with choroidal metastases (*). Discussion: Choroidal metastases (CM), the commonest intraocular malignancy, are metastatic lesions to the choroid layer of the eye. Autopsy studies (1) reported that 9% to 10% of patients who died of cancer had ocular metastasis, and most of them were localized in the choroid. CM occurs almost exclusively in metastatic disease, years after diagnosis of the primary neoplasm. Symptomatic choroidal metastases is a rare presenting manifestation of lung cancer. Choroidal metastases (CM) are metastatic lesions to the choroid layer of the eye. CM is detected in 2% to 7% of patients with metastatic lung cancer and is generally discovered at the end-stage of the disease. Singh et al. (2) reported the demographic profile, histology, disease stage, ocular and lung lesions, diagnostic and treatment (systemic and ocular) modalities, and treatment outcomes of 55 patients with choroidal metastases secondary to lung cancer : 67% of patients were male and 78% were current or ex-smokers, mean age was 55 years. Adenocarcinoma was the most common histologic type followed by squamous and small cell. Bilateral involvement was rare (<10%). Ocular treatment modalities included radiation, enucleation, and systemic steroids. Regression of choroidal metastases with treatment was observed in 67% of patients who did not undergo enucleation. Literature: (1) M.J. Donaldson, J.S. Pulido, B.P. Mullan et al. Combined positron emission tomography/computed tomography for evaluation of presumed choroidal metastases. Clin Experiment Ophthalmol, 34 (2006), pp. 846–851 (2) Singh N, Kulkarni P, Aggarwal AN, Rai Mittal B, Gupta N, Behera D, Gupta A. Choroidal metastasis as a presenting manifestation of lung cancer: a report of 3 cases and systematic review of the literature. Medicine (Baltimore). 2012 Jul;91(4):179-94.