Atlas of Ophthalmology

Regular Retina after Finishing Systemic Therapy of Interferone beta (Fundus Photography of OS)

Regular Retina after Finishing Systemic Therapy of Interferone beta (Fundus Photography of OS)
Patient: Male, 48 years of age, BCVA 0.8 at OD, 0.7 at OS; Ocular medical history: empty. General medical history: Systemic therapy with Interferone beta due to multiple sklerosis over several months. Due to ocular problems the systemic therapy with Interferon beta was stopped. Main complaint: vision deterioration since some weeks (OS<OD) Purpose: to present retinal microinfarcts associated with systemic Interferone beta and improvement of the retina after stopping the systemic Interferone beta-therapy. Method: patient undergone examination of fundus photography during and after therapy with systemic Interferone beta. Findings: (1) OS: Retinal microinfarct during therapy with Interferon beta (2) OS: Regular retina, 4 months after finishing therapy with Interferon beta Discussion: Interferons are natural glycoproteins and have antiviral, anti-proliferative and immune regulatory functions. There are several classes including interferon alpha, beta and gamma. Interferons alpha and beta are used in the treatment of several diseases including hepatitis C, cancer and immune-mediated conditions such as multiple sclerosis. Nearly 500 cases of ophthalmological complications related to interferon have been reported (1). The main ophthalmological complication from interferon treatment is essentially a vascular retinopathy with soft exudates, hemorrhages or retinal ischemia. Hayasaka et al. (2) reported that systemic hypertension and diabetes mellitus were clear risk factors for eye disease during therapy with interferons. Frequent exposure to interferon may induce the production of autoantibodies leading to the deposition of immune complexes in the retina or retinal vessels (3). Literature: (1) Fragoso YD, Paggiaro MS, Mastromauro R, Jacondino Gda S, Wilson HM. Literature systematic review on the ophthalmological side effects of interferons. Arq Bras Oftalmol. 2011 Jul-Aug;74(4):306-10. (2) Hayasaka S, Nagaki Y, Matsumoto M, Sato S. Interferon associated retinopathy. Br J Ophthalmol. 1998;82(3):323-5. (3) Lohmann CP, Kroher G, Bogenrieder T, Spiegel D, Preuner J. Severe loss of vision during adjuvant interferon alfa-2b treatment for malignant melanoma. Lancet. 1999;353(9161): 1326
Kaldefoss, Kristine, Dr.med., Augenklinik, Universität Erlangen-Nürnberg, Erlangen, Germany
H35.0
Retina -> Toxic Retinopathies; see also Light Toxicitiy -> Retinal Microinfarct Associated with Systemic Therapy of Interferone beta (Fundus Photography of OD & OS)
INF beta, complication, retina, Cotton Wool Spot
9373
Copyright @ Online Journal of Ophthalmology

-------------------------- -------------------------- -------------------------- -------------------------- -------------------------- -------------------------- -------------------------- -------------------------- -------------------------- -------------------------- -------------------------- --------------------------

© OnJOph.com