Retinal Toxicity Associated With Chloroquine (OD, OCT)
Retinal Toxicity Associated With Chloroquine (OD, OCT)
Spectral OCT (Heidelberg Engineering, Germany) revealed an impairment of outer nuclear layer, external limoting membrane, junction of the inner and outer photoreceptor segment layers (IS/OS), and retinal pigment epithelium layer (=area between arrows).
52 years of age, male, BCVA RA cc 0.1, LA cc 0.1.
To report the detailed clinical findings of a patient with retinal toxicity that developed secondary to the use of chloroquine over 15 years due to lupus erythematodes. The duration of hydroxychloroquine therapy was 15 years with a daily dosage of hydroxychloroquine of 250 mg per day (1993-2008). The presenting symptom was difficulty with reading.
Ophthalmologic examination, fundus photography, visual field testing, and detailed electrophysiologic assessment were undertaken and spectral domain optical coherence tomography was performed.
Ackermann, Andreas, Dr.med., Dept. Ophthalmology, Friedrich-Alexander University, Erlangen, Germany; Michelson, Georg, Prof. Dr. med., Interdisziplinäres Zentrum für augenheilkundliche Präventivmedizin, Augenklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
