Atlas of Ophthalmology

Corneal Edema in Fuchs Dystrophy after Regular Cataract Surgery (Colour Photography, Endothelcell-Image)

Cornea -> Dystrophies, Hereditary Keratopathies, Bilateral -> Endothelial Dystrophies -> Fuchs' Combined Corneal Dystrophy
Patient: 71 years of age, female, BCVA pre-operative 0.4; post-operative 0.4. General Medical History: empty. Ocular Medical History: in 03/2013 regular cataract surgery. Main Complaint: in 05/2012 no visual rehabilitation after cataract surgery. Methods: pre- and postoperativly colour photography, pachmetry, and corneal endothelial cell count (Rhinetec Sea Eagle Endothel). Findings: (1) Colour photography: preoperative: no haze, post-operative: haze and guttae (white arrows), border of rhexis (yellow arrows). (2) Pachmetry preoperative: 591µm post-operative: 633µm (3) Corneal endothelelial cell count. preoperative: 969 post-operative: 963 cells/mm² Discussion Fuchs' corneal dystrophy - a dominantly inherited disorder - is a slowly progressive, bilateral corneal dystrophy that affects corneal endothelial cells. Cataract surgery is a risk factor for corneal endothelial cell loss. Corneal endothelial cell loss, a major complication that sometimes occurs after cataract surgery, can lead to corneal edema and decompensation if cell density falls to 500 cells/mm2 or below. Yamazoe et al (1) reported that the mean rate of endothelial cell loss is about 12% ± 23%. Seitzman et al (2) reported a series of patients with Fuchs' dystrophy (136 eyes) undergoing cataract surgery. The average preoperative corneal thickness ranged from 482 to 674 µm. 37% had preoperative corneal thickness of 600 µm or thicker. Of eyes with preoperative pachymetry measurements of 600 µm or thicker, 10% progressed to penetrating keratoplasty. Patients with a preoperative corneal thickness of >640 μm had a 22.2% rate of requiring a corneal transplant. Their data suggest that current cataract removal techniques allow for excellent visual rehabilitation in patients with Fuchs' dystrophy who have a preoperative corneal thickness lower than 600 µm. They recommend a concurrent penetrating keratoplasty with cataract surgery in patients with Fuchs' dystrophy and a corneal thickness of >640 μm. Literature (1) Yamazoe K, Yamaguchi T, Hotta K, Satake Y, Konomi K, Den S, Shimazaki J. Outcomes of cataract surgery in eyes with a low corneal endothelial cell density. J Cataract Refract Surg. 2011 Dec;37(12):2130-6. (2) Seitzman GD, Gottsch JD, Stark WJ. Cataract surgery in patients with Fuchs' corneal dystrophy: expanding recommendations for cataract surgery without simultaneous keratoplasty. Ophthalmology. 2005 Mar;112(3):441-6.

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